Invasiveness of pneumococcal serotypes and clones circulating in Portugal before widespread use of conjugate vaccines revealing heterogeneous behavior of clones expressing the same serotype
نویسندگان
چکیده
1 Instituto de Tecnologia Química e Biológica, Universidade Nova de Lisboa, Oeiras, Portugal; 2 Centro de Química e Bioquímica, Departamento de Química e Bioquímica, 10 Faculdade de Ciências da Universidade de Lisboa, Lisboa, Portugal; 3 Instituto de Microbiologia, Instituto de Medicina Molecular, Faculdade de Medicina, Universidade de Lisboa, Lisboa, Portugal; 4 Laboratory of Microbiology, The Rockefeller University, New York, NY, USA. 15 Corresponding author: Raquel Sá-Leão Mailing address: Instituto de Tecnologia Química e Biológica, Rua da Quinta Grande, 6, Oeiras, 2780-156 Oeiras, Portugal. Phone: (351) 21 446 9872. Fax: (351) 21 4428766. E-mail: rsaleao@itqb.unl.pt 20 *These authors contributed equally to this work
منابع مشابه
Analysis of invasiveness of pneumococcal serotypes and clones circulating in Portugal before widespread use of conjugate vaccines reveals heterogeneous behavior of clones expressing the same serotype.
To estimate the invasive disease potential of serotypes and clones circulating in Portugal before extensive use of the seven-valent pneumococcal conjugate vaccine, we analyzed 475 invasive isolates recovered from children and adults and 769 carriage isolates recovered from children between 2001 and 2003. Isolates were serotyped and genotyped by pulsed-field gel electrophoresis, and a selection ...
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تاریخ انتشار 2011